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Konjac Glucomannan ​Uses And Pharmacology
- Mar 26, 2020 -

Konjac Glucomannan Uses And Pharmacology


GI effects

一级毛片免费完整视频Polysaccharides, such as glucomannan, guar gum (composed of galactose and mannose; galactomannan), tragacanth, cellulose, methylcellulose, pectin, and wheat bran, have found use as foodstuffs and, more recently, as dietary and therapeutic agents. Their ability to swell by the absorption of water has made them useful as laxatives. Additionally, konjac glucomannan has been investigated for its role as a prebiotic, an agent that stimulates the growth and activity of beneficial gut flora, including Bifidobacterium and Lactobacillus species.


Animal data

Konjac mannan has been reported to alleviate moderate constipation in 1 to 2 days and reduces fecal flora by a factor of 1,000 in 10 days. Research on microflora in mice and rats suggests a diet that includes konjac mannan alters microbial metabolism in the intestine. The study noted that in animals bearing human microflora, the differences in microbial composition were only slight despite the metabolic differences observed. A study determined that both unhydrolyzed konjac glucomannan and konjac glucomannan hydrolysate increased cecal anaerobes and bifidobacteria in Balb/c mice at 2 and 4 weeks following dietary consumption. Of note, glucomannan hydrolysate had a 2- to 4- fold larger anaerobe count at 4 weeks compared with unhydrolyzed glucomannan and cellulose treatment groups. Both unhydrolyzed glucomannan and glucomannan hydrolysate decreased cecal Clostridium perfringens, a potentially harmful bacterium, at week 4. Both of these compounds modulated fecal and cecal flora in a dose-dependent fashion.8 In another similar study, 5% wkonjac glucomannan hydrolysate fed to Wister mice for 14 weeks stimulated the growth of fecal anaerobes and lactobacilli compared with the control group (P < 0.001). The compound was also able to decrease counts of fecal Escherichia coli and C. perfringens.

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